Memory and Aging

Memory is not just one thing–it is a collection of abilities that allows us to change our behavior in response to previous experiences. The timescale of memory includes information from what just happened a second ago to events that occurred decades ago. Research on the cognitive and biological underpinnings of memory reveals that there is not just one memory system in the brain, rather there are many specialized systems that give us the ability to hold information in mind while it’s needed (working memory), the ability to learn new skills or habits (non-declarative or implicit memory), and the ability to learn new facts and events (declarative or explicit memory).

The number one cognitive complaint in healthy older adults is a decrease in memory ability, usually in our ability to remember events (known as episodic memory). Some memory changes are normal and to be expected. It seems that as we get older we rely less on memory for specific details and more on the general gist of what happened. There may be structural changes happening in the brain that support this change.

Dementias are cognitive disorders associated with age characterized by memory impairment and impairment in at least one other cognitive domain that impairs social or occupational functioning characterized by a gradual onset and continual decline. Alzheimer’s disease (AD) is the most common form of dementia, accounting for about 62% of cases. The number one risk factor for AD is age.

Are there things you can do to reduce your risk of AD and other dementias? The best evidence suggests staying active physically, mentally, and socially. All these domains are associated with lower risk of developing AD.

Below are resources on memory, aging, and dementia in case you would like to learn more.

Memory References

Astill Wright, L., Horstmann, L., Holmes, E. A., & Bisson, J. I. (2021). Consolidation/reconsolidation therapies for the prevention and treatment of PTSD and re-experiencing: A systematic review and meta-analysis. Translational Psychiatry, 11(1), Article 1. https://doi.org/10.1038/s41398-021-01570-w

Augustinack, J. C., Helmer, K., Huber, K. E., Kakunoori, S., Zollei, L., & Fischl, B. (2010). Direct visualization of the perforant pathway in the human brain with ex vivo diffusion tensor imaging. Frontiers in human neuroscience, 4, 42. https://doi.org/10.3389/fnhum.2010.00042

Baddeley, A. D., Hitch, G. J., & Allen, R. J. (2019). From short-term store to multicomponent working memory: The role of the modal model. Memory & cognition, 47(4), 575-588.

Bahrick, H. P., & Phelps, E. (1988). Maintenance of marginal knowledge. In Remembering reconsidered: Ecological and traditional approaches to the study of memory. Cambridge University Press.

Bearden, C. E., Thompson, P. M., Avedissian, C., Klunder, A. D., Nicoletti, M., Dierschke, N., . . . Soares, J. C. (2009). Altered hippocampal morphology in unmedicated patients with major depressive illness. ASN Neuro, 1(4). https://doi.org/10.1042/AN20090026

Blackburn, J. M. (1936). The acquisition of skill: An analysis of learning curves. HM Stationery Office.

Boyke, J., Driemeyer, J., Gaser, C., Buchel, C., & May, A. (2008). Training-induced brain structure changes in the elderly. J Neurosci, 28(28), 7031-7035. https://doi.org/10.1523/JNEUROSCI.0742-08.2008

Cahill, L., & McGaugh, J. L. (1995). A novel demonstration of enhanced memory associated with emotional arousal. Conscious Cogn, 4(4), 410-421. https://doi.org/10.1006/ccog.1995.1048

Cahill, L., & McGaugh, J. L. (1996). Modulation of memory storage. Curr Opin Neurobiol, 6(2), 237-242.

Chen, Y., Dube, C. M., Rice, C. J., & Baram, T. Z. (2008). Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci, 28(11), 2903-2911. https://doi.org/10.1523/JNEUROSCI.0225-08.2008

Collingridge, G. L., Kehl, S. J., & McLennan, H. (1983). Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol, 334, 33-46. https://doi.org/10.1113/jphysiol.1983.sp014478

Craik, F. I., & Simon, E. (1980). Age differences in memory: The roles of attention and depth of processing. New directions in memory and aging, 95-112.

Crossman, E. R. F. W. (1959). A theory of the acquisition of speed-skill∗. Ergonomics, 2(2), 153-166.

De Groot, A. D. (2014). Thought and choice in chess (Vol. 4). Walter de Gruyter GmbH & Co KG.

Dewar, M., Alber, J., Butler, C., Cowan, N., & Della Sala, S. (2012). Brief Wakeful Resting Boosts New Memories Over the Long Term. Psychological Science, 23(9), 955–960. https://doi.org/10.1177/0956797612441220

Ebbinghaus, H.-. (1885). Uber das Gedachtnis. Untersuchungen zur experimentellen Psychologie, von Herm. Ebbinghaus. In: Leipzig, Duncker and Humblot.

Farhani, F., Shahrbanian, S., Auais, M., Hekmatikar, A. H. A., & Suzuki, K. (2022). Effects of Aerobic Training on Brain Plasticity in Patients with Mild Cognitive Impairment: A Systematic Review of Randomized Controlled Trials. Brain Sciences, 12(6), Article 6. https://doi.org/10.3390/brainsci12060732

Ferguson, S. A., Hashtroudi, S., & Johnson, M. K. (1992). Age differences in using source-relevant cues. Psychol Aging, 7(3), 443-452.

Hara, Y., Rapp, P. R., & Morrison, J. H. (2012). Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age (Dordr), 34(5), 1051-1073. https://doi.org/10.1007/s11357-011-9278-5

Hebb, D. O. (1949). The Organization of Behavior. New York: John Wiley & Sons.

Henkel, L. A., Johnson, M. K., & De Leonardis, D. M. (1998). Aging and source monitoring: Cognitive processes and neuropsychological correlates. Journal of Experimental Psychology: General, 127(3), 251.

Holden, H. M., & Gilbert, P. E. (2012). Less efficient pattern separation may contribute to age-related spatial memory deficits. Frontiers in aging neuroscience, 4, 9. https://doi.org/10.3389/fnagi.2012.00009

Hyde, T. S., & Jenkins, J. J. (1973). Recall for words as a function of semantic, graphic, and syntactic orienting tasks. Journal of Verbal Learning and Verbal Behavior, 12(5), 471-480.

Jennings, J. M., & Jacoby, L. L. (1997). An opposition procedure for detecting age-related deficits in recollection: telling effects of repetition. Psychol Aging, 12(2), 352-361.

Jevons, W. S. (1871). The power of numerical discrimination. Nature, 3, 281-282.

Ji, D., & Wilson, M. A. (2007). Coordinated memory replay in the visual cortex and hippocampus during sleep. Nat Neurosci, 10(1), 100-107. https://doi.org/10.1038/nn1825

Keppel, G. (1964). Facilitation in short-and long-term retention of paired associates following distributed practice in learning. Journal of Verbal Learning and Verbal Behavior, 3(2), 91-111.

Khorshidi, F., Poljak, A., Liu, Y., Lo, J. W., Crawford, J. D., & Sachdev, P. S. (2021). Resveratrol: A “miracle” drug in neuropsychiatry or a cognitive enhancer for mice only? A systematic review and meta-analysis. Ageing Research Reviews, 65, 101199. https://doi.org/10.1016/j.arr.2020.101199

LePort, A. K., Stark, S. M., McGaugh, J. L., & Stark, C. E. (2017). A cognitive assessment of highly superior autobiographical memory. Memory, 25(2), 276-288.

McDermott, K. B., & Roediger, H. L., 3rd. (1996). Exact and conceptual repetition dissociate conceptual memory tests: problems for transfer appropriate processing theory. Can J Exp Psychol, 50(1), 57-71.

Melby-Lervag, M., & Hulme, C. (2013). Is working memory training effective? A meta-analytic review. Dev Psychol, 49(2), 270-291. https://doi.org/10.1037/a0028228

Milner, B. (1962). Les troubles de la mémoire accompagnant des lésions hippocampiques bilatérales. In Physiologie de l’Hippocampe (pp. 257-272): Centre National de la Recherhe Scientifique.

Morris, R. G. (1989). Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. J Neurosci, 9(9), 3040-3057.

Nader, K., Schafe, G. E., & Le Doux, J. E. (2000). Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature, 406(6797), 722-726. https://doi.org/10.1038/35021052

Naveh-Benjamin, M., & Mayr, U. (2018). Age-related differences in associative memory: Empirical evidence and theoretical perspectives. Psychology and Aging, 33(1), 1.

Nicholson, D. A., Yoshida, R., Berry, R. W., Gallagher, M., & Geinisman, Y. (2004). Reduction in size of perforated postsynaptic densities in hippocampal axospinous synapses and age-related spatial learning impairments. J Neurosci, 24(35), 7648-7653. https://doi.org/10.1523/JNEUROSCI.1725-04.2004

Norman, K. A., & Schacter, D. L. (1997). False recognition in younger and older adults: exploring the characteristics of illusory memories. Mem Cognit, 25(6), 838-848.

Packard, M. G., & McGaugh, J. L. (1996). Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning. Neurobiology of Learning and Memory, 65, 65-72.

Pastalkova, E., Serrano, P., Pinkhasova, D., Wallace, E., Fenton, A. A., & Sacktor, T. C. (2006). Storage of spatial information by the maintenance mechanism of LTP. Science, 313(5790), 1141-1144. https://doi.org/10.1126/science.1128657

Postman, L., & Phillips, L. W. J. Q. j. o. e. p. (1965). Short-term temporal changes in free recall. 17(2), 132-138.  

Rapp, P. R., & Gallagher, M. (1996). Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc Natl Acad Sci U S A, 93(18), 9926-9930. https://doi.org/10.1073/pnas.93.18.9926

Robitsek, R. J., Fortin, N. J., Koh, M. T., Gallagher, M., & Eichenbaum, H. (2008). Cognitive aging: a common decline of episodic recollection and spatial memory in rats. J Neurosci, 28(36), 8945-8954. https://doi.org/10.1523/JNEUROSCI.1893-08.2008

Rodrigue, K. M., & Raz, N. (2004). Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults. J Neurosci, 24(4), 956-963. https://doi.org/10.1523/JNEUROSCI.4166-03.2004

Roediger III, H. L., & Karpicke, J. D. (2006). Test-enhanced learning: Taking memory tests improves long-term retention. Psychological science, 17(3), 249-255.

Sacktor, T. C. (2008). PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage. Prog Brain Res, 169, 27-40. https://doi.org/10.1016/S0079-6123(07)00002-7

Schacter, D. L., Kaszniak, A. W., Kihlstrom, J. F., & Valdiserri, M. (1991). The relation between source memory and aging. Psychol Aging, 6(4), 559-568.

Schacter, D. L., Koutstaal, W., & Norman, K. A. (1997). False memories and aging. Trends Cogn Sci, 1(6), 229-236. https://doi.org/10.1016/S1364-6613(97)01068-1

Scholz, J., Klein, M. C., Behrens, T. E., & Johansen-Berg, H. (2009). Training induces changes in white-matter architecture. Nat Neurosci, 12(11), 1370-1371. https://doi.org/10.1038/nn.2412

Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003). Untreated depression and hippocampal volume loss. Am J Psychiatry, 160(8), 1516-1518. https://doi.org/10.1176/appi.ajp.160.8.1516

Shelton, D. J., & Kirwan, C. B. (2013). A possible negative influence of depression on the ability to overcome memory interference. Behav Brain Res, 256C, 20-26. https://doi.org/10.1016/j.bbr.2013.08.016

Simon, K. C., Gómez, R. L., & Nadel, L. (2020). Sleep’s role in memory reconsolidation. Current Opinion in Behavioral Sciences, 33, 132-137.

Snitz, B. E., O’Meara, E. S., Carlson, M. C., Arnold, A. M., Ives, D. G., Rapp, S. R., . . . Ginkgo Evaluation of Memory Study, I. (2009). Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. JAMA, 302(24), 2663-2670. https://doi.org/10.1001/jama.2009.1913

Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., . . . Phelps, C. H. (2011). Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement, 7(3), 280-292. https://doi.org/10.1016/j.jalz.2011.03.003

Squire, L. R., Schmolck, H., & Stark, S. (2001). Impaired auditory recognition memory in amnesic patients with medial temporal lobe lesions. Learning and Memory, 8, 252-256.

Standing, L. (1973). Learning 10,000 pictures. Q J Exp Psychol, 25(2), 207-222. https://doi.org/10.1080/14640747308400340

Stark, S. M., Kirwan, C. B., & Stark, C. E. (2019). Mnemonic similarity task: A tool for assessing hippocampal integrity. Trends in cognitive sciences, 23(11), 938-951.

Stefanacci, L., Buffalo, E. A., Schmolck, H., & Squire, L. R. (2000). Profound amnesia following damage to the medial temporal lobe: A neuroanatomical and neuropsychological profile of patient E.P. Journal of Neuroscience, 20, 7024-7036.

Stickgold, R., & Walker, M. P. (2005). Memory consolidation and reconsolidation: what is the role of sleep? Trends Neurosci, 28(8), 408-415. https://doi.org/10.1016/j.tins.2005.06.004

Talarico, J. M., & Rubin, D. C. (2003). Confidence, not consistency, characterizes flashbulb memories. Psychol Sci, 14(5), 455-461. https://doi.org/10.1111/1467-9280.02453

Tang, Y. P., Shimizu, E., Dube, G. R., Rampon, C., Kerchner, G. A., Zhuo, M., . . . Tsien, J. Z. (1999). Genetic enhancement of learning and memory in mice. Nature, 401(6748), 63-69. https://doi.org/10.1038/43432

Teng, E., & Squire, L. R. (1999). Memory for places learned long ago is intact after hippocampal damage. Nature, 400(6745), 675-677.

Voss, M. W., Vivar, C., Kramer, A. F., & Praag, H. van. (2013). Bridging animal and human models of exercise-induced brain plasticity. Trends in Cognitive Sciences, 17(10), 525–544. https://doi.org/10.1016/j.tics.2013.08.001

Wilson, I. A., Gallagher, M., Eichenbaum, H., & Tanila, H. (2006). Neurocognitive aging: prior memories hinder new hippocampal encoding. Trends Neurosci, 29(12), 662-670. https://doi.org/10.1016/j.tins.2006.10.002

Wilson, I. A., Ikonen, S., Gallagher, M., Eichenbaum, H., & Tanila, H. (2005). Age-associated alterations of hippocampal place cells are subregion specific. J Neurosci, 25(29), 6877-6886. https://doi.org/10.1523/JNEUROSCI.1744-05.2005

Yassa, M. A., Mattfeld, A. T., Stark, S. M., & Stark, C. E. (2011). Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proc Natl Acad Sci U S A, 108(21), 8873-8878. https://doi.org/10.1073/pnas.1101567108

Yassa, M. A., Muftuler, L. T., & Stark, C. E. (2010). Ultrahigh-resolution microstructural diffusion tensor imaging reveals perforant path degradation in aged humans in vivo. Proc Natl Acad Sci U S A, 107(28), 12687-12691. https://doi.org/10.1073/pnas.1002113107